The Use of Novel, Rapid Analytical Tools in the Assessment of the Stability of Tablets—A Pilot Analysis of Expired and Unexpired Tablets Containing Nifuroxazide

In the analysis of finished pharmaceutical products, numerous innovative analytical techniques are often used, i.e., Raman spectroscopy, scanning electron microscopy, computer microtomography, directional hemispherical reflectance, and hyperspectral analyses. These allow for identification changes in solid phases. Many advantages over other can be attributed to these techniques, e.g., they rapid, non-destructive, comprehensive. They occurring However, above-mentioned methods still not standard procedures research. The present study aimed assess possible usefulness total reflectance (THR), imaging, microtomography evaluate stability tablets containing nifuroxazide during storage. study, expired unexpired coating (n = 10 each) were analyzed. addition, four stored at 40°C 3 months (stressed tablets). Reflectance was determined with seven wavelength bands from 335 nm 2500 using an SOC-410 Directional Hemispherical Reflectometer (Surface Optics Corporation, San Diego, CA, USA). A Specim IQ camera (Spectral Imaging Ltd., Oulu, Finland) used a range 400–1030 nm. Tablets also scanned X-ray (Phoenix v?tome?x, GE Sensing & Inspection Technologies GmbH, Wunstorf, Germany). results indicated that lower than all spectral bands, except 700–1100 1700–2500 turn, stressed showed higher THR values 1000–1700 homogeneity tablets, as well microtomographic tablet density thickness, parameters differed significantly between analyzed tablets.